Polynucleotide Injections for Skin Repair & Regeneration

Biological support for compromised, inflamed, or ageing skin.

Polynucleotides are regenerative skin injectables derived from purified DNA fragments that support cellular repair, wound healing, and collagen synthesis. Clinically effective for sensitive, compromised, or ageing skin, polynucleotide treatments like Plinest and Vitaraan help repair the extracellular matrix, improve skin elasticity, and reduce inflammation at the cellular level.

Polynucleotide Injections

Stimulate natural skin regeneration.

Polynucleotides are one of the most exciting breakthroughs in regenerative skin health — injectable biostimulators that encourage your skin to heal, repair, and strengthen from within. Derived from purified salmon DNA, these molecules activate your skin’s natural processes: boosting hydration, collagen production, and cell renewal for visibly healthier, calmer, and more resilient skin.

Every 3–4 weeks

Mild swelling or bruising possible (1–3 days)

2–4 sessions, spaced 3–4 weeks apart

Gradual – noticeable improvement from 2–4 weeks onwards

Mild – small injections, numbing optional

45 minutes

  • Unlike dermal fillers, polynucleotide treatments do not alter facial volume or shape. Instead, they signal the skin to regenerate — improving tone, elasticity, hydration, and structure over time. We offer a curated range of polynucleotide products for the face, neck, and under-eye area, including Illumiluna, Plenhyage, Planest, and Vitaran.

  • Polynucleotides are ideal for:

    • Fine lines, thinning, or crepey skin

    • Hollowing, pigmentation, or laxity under the eyes

    • Dehydrated, sensitive, or post-acne skin

    • Mild rosacea, redness, or inflammation

    • Skin in need of structural support without added volume

    • Clients wanting repair without filler

    • Improves elasticity, tone, and dermal density

    • Reduces redness, dullness, and post-acne scarring

    • Brightens and softens the under-eye area

    • Stimulates long-term collagen and cellular repair

    • Deeply hydrates and restores skin resilience

    • Fully biocompatible and safe for most skin types

  • Each treatment includes:

    • Consultation + skin assessment

    • Optional numbing cream for comfort

    • Microinjections placed with precision across the treatment area

    • Polynucleotide formulation tailored to your skin zone and needs

    • Post-treatment aftercare guidance

    No harsh acids or chemicals — just biologically active compounds designed to support your skin’s natural intelligence.

  • Before your session:

    • Avoid alcohol, anti-inflammatories, and blood thinners for 24 hours

    • Discontinue retinoids or exfoliants for 3–5 days

    • Inform us of recent injectables, skin treatments, or medication changes

    • Skin must be intact — no cold sores, breakouts, or infections

    Not suitable if you:

    • Are pregnant or breastfeeding

    • Have an allergy to salmon or marine DNA

    • Have autoimmune conditions (assessed individually)

    • Are taking immunosuppressants or anticoagulants

    • Have active infections or compromised skin barrier

    • Mild swelling or tiny bumps are normal and subside within 24–72 hours

    • Do not touch, massage, or apply makeup for 24 hours

    • Avoid heat, steam, or intense exercise for 48 hours

    • Use gentle, hydrating skincare and SPF

    • Results build gradually over 2–4 weeks, with continued improvement after each session

  • Consider pairing with:

    • Calecim Exosomes – £25

    • LED Light Therapy – £20

    • Neck Extension – £30

    • AnteAge Growth Factors – £70

    • Soothing Mask Add-On – £15

    Your practitioner will guide you through combinations that support deeper regeneration.

  • Illumiluna Eyes - £220
    Eyes only | 1ml | ~7.5mg/ml

    Plenhyage / Planest Eyes - £280
    Eyes only | 2ml | ~10mg/ml

    Vitaran - £250
    Face & Neck | 1ml | ~10mg/ml

    Plenhyage / Planest - £300
    Face & Neck | 2ml | ~10mg/ml

    2ml treatments are typically split into 1ml per session for balanced dosing.

    Courses of 2–4 sessions spaced 3–4 weeks apart are recommended for full effect, with maintenance every 4–6 months.

  • “My under-eyes look fresher and smoother with no filler in sight. I finally look well-rested!”
    — Clare, 41

    “I noticed subtle but significant improvements — my skin just looks healthier and stronger.”
    — Meera, 46

  • Is this the same as filler?
    No. Polynucleotides regenerate tissue — they do not add volume or reshape the face.

    How many sessions will I need?
    Most clients begin with 2–4 sessions spaced 3–4 weeks apart. We recommend top-ups every 4–6 months for lasting support.

    Can I combine this with other treatments?
    Yes — it works beautifully alongside microneedling, mesotherapy, and skin boosters. We’ll guide your plan.

    Will I bruise or swell?
    Mild swelling or pinpoint bumps can occur, especially under the eyes, but typically resolve within 1–3 days.

    Is it safe for sensitive skin?
    Yes. Polynucleotides are anti-inflammatory and often help strengthen compromised or reactive skin over time.

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“Polynucleotides act as biological bio-stimulators, accelerating dermal repair and collagen remodelling.” – Journal of Cosmetic Dermatology