Polynucleotide Injections and Facial Therapy for Skin Repair & Regeneration

Biological support for compromised, inflamed, or ageing skin - from targeted injectables to full facial protocols.

Polynucleotides are regenerative skin treatments derived from purified DNA fragments that support cellular repair, wound healing, and collagen synthesis. Clinically effective for sensitive, compromised, or ageing skin, polynucleotide therapies such as injectables (PLINEST, Vitaran) and the DB Polynucleotide Facial help repair the extracellular matrix, improve elasticity, calm inflammation, and strengthen the skin barrier. Whether delivered through precision injections or as part of a complete facial ritual with mesotherapy, mask, and LED therapy, these treatments provide layered support for healthier, more resilient skin.

Polynucleotide Injections

Stimulate natural skin regeneration.

Polynucleotides are one of the most exciting breakthroughs in regenerative skin health — injectable biostimulators that encourage your skin to heal, repair, and strengthen from within. Derived from purified salmon DNA, these molecules activate your skin’s natural processes: boosting hydration, collagen production, and cell renewal for visibly healthier, calmer, and more resilient skin.

Every 3–4 weeks

Mild swelling or bruising possible (1–3 days)

2–4 sessions, spaced 3–4 weeks apart

Gradual – noticeable improvement from 2–4 weeks onwards

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Mild – small injections, numbing optional

45 minutes

  • Unlike dermal fillers, polynucleotide treatments do not alter facial volume or shape. Instead, they signal the skin to regenerate — improving tone, elasticity, hydration, and structure over time. We offer a curated range of polynucleotide products for the face, neck, and under-eye area, including PLINEST, Plenhyage, Illuma Luna, and Vitaran.

  • Polynucleotides are ideal for:

    • Fine lines, thinning, or crepey skin

    • Hollowing, pigmentation, or laxity under the eyes

    • Dehydrated, sensitive, or post-acne skin

    • Mild rosacea, redness, or inflammation

    • Skin in need of structural support without added volume

    • Clients wanting repair without filler

    • Improves elasticity, tone, and dermal density

    • Reduces redness, dullness, and post-acne scarring

    • Brightens and softens the under-eye area

    • Stimulates long-term collagen and cellular repair

    • Deeply hydrates and restores skin resilience

    • Fully biocompatible and safe for most skin types

    • Consultation and skin assessment

    • Optional numbing cream for comfort

    • A series of microinjections placed with precision across the treatment area

    • A tailored cocktail of polynucleotides designed for your specific skin needs

    • Post-treatment aftercare guidance

  • Before your session:

    • Avoid alcohol, anti-inflammatories, and blood thinners for 24 hours

    • Discontinue retinoids or exfoliants for 3–5 days

    • Inform us of recent injectables, skin treatments, or medication changes

    • Skin must be intact — no cold sores, breakouts, or infections

    Not suitable if you:

    • Are pregnant or breastfeeding

    • Have an allergy to salmon or marine DNA

    • Have autoimmune conditions (assessed individually)

    • Are taking immunosuppressants or anticoagulants

    • Have active infections or compromised skin barrier

    • Mild swelling or tiny bumps are normal and subside within 24–72 hours

    • Do not touch, massage, or apply makeup for 24 hours

    • Avoid heat, steam, or intense exercise for 48 hours

    • Use gentle, hydrating skincare and SPF

    • Results build gradually over 2–4 weeks, with continued improvement after each session

  • Consider pairing with:

    • Calecim Exosomes – £25

    • LED Light Therapy – £20

    • Neck Extension – £30

    • AnteAge Growth Factors – £70

    • Soothing Mask Add-On – £15

    Your practitioner will guide you through combinations that support deeper regeneration.

  • Illuma Luna Eyes - £220
    Eyes only | 1ml | ~7.5mg/ml

    Plenhyage / PLINEST Eyes - £280
    Eyes only | 2ml | ~10mg/ml

    Vitaran - £250
    Face & Neck | 1ml | ~10mg/ml

    Plenhyage / PLINEST - £300
    Face & Neck | 2ml | ~10mg/ml

    2ml treatments are typically split into 1ml per session for balanced dosing.

    Courses of 2–4 sessions spaced 3–4 weeks apart are recommended for full effect, with maintenance every 4–6 months.

  • “My under-eyes look fresher and smoother with no filler in sight. I finally look well-rested!”
    — Clare, 41

    “I noticed subtle but significant improvements — my skin just looks healthier and stronger.”
    — Meera, 46

  • Is this the same as filler?
    No. Polynucleotides regenerate tissue — they do not add volume or reshape the face.

    How many sessions will I need?
    Most clients begin with 2–4 sessions spaced 3–4 weeks apart. We recommend top-ups every 4–6 months for lasting support.

    Can I combine this with other treatments?
    Yes — it works beautifully alongside microneedling, mesotherapy, and skin boosters. We’ll guide your plan.

    Will I bruise or swell?
    Mild swelling or pinpoint bumps can occur, especially under the eyes, but typically resolve within 1–3 days.

    Is it safe for sensitive skin?
    Yes. Polynucleotides are anti-inflammatory and often help strengthen compromised or reactive skin over time.

DB Polynucleotide Facial

Advanced regeneration for skin, naturally restored.

The DB Polynucleotide Facial offers cutting-edge skin regeneration using PLINEST Polynucleotides. In a full session, we combine deep injection and mesotherapy infusion of polynucleotides, followed by soothing mask and LED therapy, to support repair, boost firmness, and restore healthy glow. Ideal for skin under stress, showing early signs of ageing, or needing structural renewal without dramatic volume.

Every 3–4 weeks

Mild swelling or bruising possible (1–3 days)

3 sessions for optimal results

From ~2 weeks; cumulative with course

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Mild–moderate
(numbing optional)

75 minutes

  • The DB Polynucleotide Facial is our most advanced regenerative treatment — combining the power of PLINEST Polynucleotides (PN-HPT®) with a complete, results-driven facial ritual.

    • Step 1: Deep repair — 2 ml of PLINEST polynucleotides are delivered via injections to strengthen the deeper layers of the skin.

    • Step 2: Surface renewal — 2 ml are then delivered through mesotherapy (microneedling infusion) to target tone and texture.

    • Total dose — 4 ml of PLINEST (≈80 mg of polynucleotides) in one session, one of the highest doses available in a single facial.

    • Finishing ritual — a soothing mask and LED light therapy calm, hydrate, and accelerate repair.

    Results: Skin appears brighter and fresher immediately, with progressive improvements in firmness, elasticity, and overall health in the following weeks.

  • DB Polynucleotide Facials are ideal for:

    • Fine lines, wrinkles, and thinning skin

    • Loss of firmness or elasticity

    • Dull, tired or stressed skin

    • Uneven tone, scarring or sun damage

    • Sensitive or reactive skin needing repair

    • Anyone seeking regenerative results beyond hydration or filler

    • High-dose delivery: 4 ml of PLINEST (≈80 mg polynucleotides) per session

    • Stimulates collagen, elastin, and fibroblast activity

    • Repairs and restores skin structure at a cellular level

    • Improves elasticity, firmness, and hydration

    • Calms redness and supports barrier function

    • Enhances radiance, texture, and overall glow

    • Non-volumising — results look natural, not altered

    • Consultation and skin assessment

    • Optional numbing cream for comfort

    • Injections with 2 ml of PLINEST polynucleotides to repair and strengthen deeper layers

    • Mesotherapy infusion with 2 ml of PLINEST to refine surface tone and texture

    • Soothing mask to calm and hydrate the skin

    • LED light therapy to accelerate repair and reduce inflammation

    • Post-treatment aftercare guidance

  • Before your session:

    • Avoid alcohol, aspirin, and anti-inflammatories for 24 hours prior

    • Discontinue retinoids, acids, and exfoliants 3–5 days before

    • Do not schedule laser, microneedling, or filler in the area within 2 weeks

    • Arrive makeup-free if possible

    Not suitable if you:

    • Are pregnant or breastfeeding

    • Have active skin infections, cold sores, or open wounds

    • Are allergic to salmon or fish-derived products

    • Are on strong acne or immunosuppressive medication

    • Have had injectables in the same area within the last 2 weeks

    • Have autoimmune conditions, a history of hypersensitivity reactions, or are taking photosensitising medication

    • Expect small bumps or mild redness at injection sites (settle within 24–48 hours)

    • Avoid touching or applying makeup for 24 hours

    • No heat, saunas, or intense exercise for 48 hours

    • Gentle hydrating skincare and SPF only for the first few days

    • Results build gradually from 2 weeks and improve further with each session

  • Consider pairing with:

    • Calecim Exosomes – £25
      Cellular communication boosters to enhance repair and recovery.

    • LED Light Therapy – £20
      Gentle light energy to reduce inflammation and support healing.

    • Neck Extension – £30
      Extend regenerative benefits beyond the face for continuity of care.

    • AnteAge Growth Factors – £70
      Potent bio-signals to amplify collagen and tissue support.

    • Soothing Mask Add-On – £15
      Calms post-treatment sensitivity while locking in hydration.

    Your practitioner will guide you through combinations that support deeper regeneration.

  • £420 per session

    Course of 3 sessions: £1,008 (20% discount applied – saving £252)

  • “Immediately after treatment, my skin felt plumper and looked noticeably fresher. After 2 weeks, the fine lines around my eyes had softened and I could see improved radiance.”
    — Lisa, 37

    “I came in with sun-damaged, leathery skin and left with a hydrated, glowing face. The polynucleotide injections were done with precision, no bruising, and the results speak for themselves.”
    — Rita, 44

  • What are polynucleotides?
    They are purified DNA fragments (derived from salmon) that stimulate your body’s natural repair mechanisms — improving hydration, firmness, and resilience at a cellular level.

    Why PLINEST?
    PLINEST is the original, medical-grade polynucleotide brand with 20 mg/ml concentration. With our DB Polynucleotide Facial you receive 4 ml per session — equal to ~80 mg polynucleotides — a higher dose than many standard injectable protocols.

    How many sessions will I need?
    We recommend a course of 3 treatments, spaced 3–4 weeks apart, with maintenance every 6–9 months.

    Is this the same as filler?
    No — polynucleotides regenerate and repair tissue; they do not add volume. Results are natural, progressive, and restorative.

    Is there downtime?
    Most clients resume normal activities the next day. Mild redness, bumps, or swelling can appear but resolve within a few days.

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“Polynucleotides act as biological bio-stimulators, accelerating dermal repair and collagen remodelling.” – Journal of Cosmetic Dermatology